Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula†
dc.contributor.author | Kwan, Jason C. | |
dc.contributor.author | Teplitski, Max | |
dc.contributor.author | Gunasekera, Sarath | |
dc.contributor.author | Paul, Valerie J. | |
dc.contributor.author | Luesch, Hendrik | |
dc.date.accessioned | 2010-11-18T19:12:33Z | |
dc.date.available | 2010-11-18T19:12:33Z | |
dc.date.issued | 2010 | |
dc.description.abstract | A new stereoisomer of malyngamide C, 8-epi-malyngamide C (1), and the known compound lyngbic acid [(4E,7S)-7-methoxytetradec-4-enoic acid] were isolated from a sample of Lyngbya majuscula collected near Bush Key, Dry Tortugas, Florida. The structure of 1 was determined by NMR and MS experiments. The absolute configuration of 1 was determined by selective Mitsunobu inversion of C-8 to give malyngamide C, as determined by NMR, MS, and comparison of specific rotation. Both 1 and malyngamide C were found to be cytotoxic to HT29 colon cancer cells (IC50 15.4 and 5.2 μM, respectively) and to inhibit bacterial quorum sensing in a reporter gene assay. | |
dc.format.extent | 463–466 | |
dc.identifier | 0163-3864 | |
dc.identifier.citation | Kwan, Jason C., Teplitski, Max, Gunasekera, Sarath, Paul, Valerie J., and Luesch, Hendrik. 2010. "<a href="https://repository.si.edu/handle/10088/11207">Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula†</a>." <em>Journal of natural products</em>, 73, (3) 463–466. <a href="https://doi.org/10.1021/np900614n">https://doi.org/10.1021/np900614n</a>. | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.uri | http://hdl.handle.net/10088/11207 | |
dc.relation.ispartof | Journal of natural products 73 (3) | |
dc.title | Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula† | |
dc.type | article | |
sro.description.unit | NH-SMS | |
sro.description.unit | NMNH | |
sro.identifier.doi | 10.1021/np900614n | |
sro.identifier.itemID | 82019 | |
sro.identifier.refworksID | 51153 | |
sro.identifier.url | https://repository.si.edu/handle/10088/11207 |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- sms_814_Kwan_et_al_2010.pdf
- Size:
- 255.64 KB
- Format:
- Adobe Portable Document Format