Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula†

Abstract

A new stereoisomer of malyngamide C, 8-epi-malyngamide C (1), and the known compound lyngbic acid [(4E,7S)-7-methoxytetradec-4-enoic acid] were isolated from a sample of Lyngbya majuscula collected near Bush Key, Dry Tortugas, Florida. The structure of 1 was determined by NMR and MS experiments. The absolute configuration of 1 was determined by selective Mitsunobu inversion of C-8 to give malyngamide C, as determined by NMR, MS, and comparison of specific rotation. Both 1 and malyngamide C were found to be cytotoxic to HT29 colon cancer cells (IC50 15.4 and 5.2 μM, respectively) and to inhibit bacterial quorum sensing in a reporter gene assay.

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Kwan, Jason C., Teplitski, Max, Gunasekera, Sarath, Paul, Valerie J., and Luesch, Hendrik. 2010. "<a href="https://repository.si.edu/handle/10088/11207">Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula†</a>." <em>Journal of natural products</em>, 73, (3) 463–466. <a href="https://doi.org/10.1021/np900614n">https://doi.org/10.1021/np900614n</a>.

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