Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity

dc.contributor.authorBalunas, Marcy J.
dc.contributor.authorLinington, Roger G.
dc.contributor.authorTidgewell, Kevin
dc.contributor.authorFenner, Amanda M.
dc.contributor.authorUrena, Luis-David
dc.contributor.authorTogna, Gina Della
dc.contributor.authorKyle, Dennis E.
dc.contributor.authorGerwick, William H.
dc.date.accessioned2010-04-05T13:56:32Z
dc.date.available2010-04-05T13:56:32Z
dc.date.issued2010
dc.description.abstractTropical parasitic and infectious diseases, such as leishmaniasis, pose enormous global health threats, but are largely neglected in commercial drug discovery programs. However, the Panama International Cooperative Biodiversity Group (ICBG) has been working to identify novel treatments for malaria, Chagas’ disease, and leishmaniasis through an investigation of plants and microorganisms from Panama. We have pursued activity-guided isolation from an extract of Lyngbya majuscula that was found to be active against leishmaniasis. A new modified linear peptide from the dragonamide series was isolated, dragonamide E (1), along with two known modified linear peptides, dragonamide A (2) and herbamide B (3). Dragonamides A and E and herbamide B exhibited antileishmanial activity with IC50 values of 6.5, 5.1, and 5.9 µM, respectively. Spectroscopic and stereochemical data for dragonamide E (1) and herbamide B (3; the spectroscopic and stereochemical data for this substance is incomplete in the literature) are presented as well as comparisons of biological activity within the dragonamide compound family. Biosynthetic differences among marine compounds with a terminal free amide are also discussed.
dc.format.extent60–66
dc.identifier0163-3864
dc.identifier.citationBalunas, Marcy J., Linington, Roger G., Tidgewell, Kevin, Fenner, Amanda M., Urena, Luis-David, Togna, Gina Della, Kyle, Dennis E., and Gerwick, William H. 2010. "<a href="https://repository.si.edu/handle/10088/8870">Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity</a>." <em>Journal of natural products</em>, 73, (1) 60–66. <a href="https://doi.org/10.1021/np900622m">https://doi.org/10.1021/np900622m</a>.
dc.identifier.issn0163-3864
dc.identifier.urihttp://hdl.handle.net/10088/8870
dc.relation.ispartofJournal of natural products 73 (1)
dc.titleDragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity
dc.typearticle
sro.description.unitSTRI
sro.description.unitInternational Collaborative Biodiversity Groups
sro.description.unitbocas del Toro Archipelago
sro.identifier.doi10.1021/np900622m
sro.identifier.itemID81691
sro.identifier.refworksID24843
sro.identifier.urlhttps://repository.si.edu/handle/10088/8870

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