dc.contributor.author |
Campana, Michael G. |
en |
dc.contributor.author |
Parker, Lillian D. |
en |
dc.contributor.author |
Hawkins, Melissa T. R. |
en |
dc.contributor.author |
Young, Hillary S. |
en |
dc.contributor.author |
Helgen, Kristofer M. |
en |
dc.contributor.author |
Szykman Gunther, Micaela |
en |
dc.contributor.author |
Woodroffe, Rosie |
en |
dc.contributor.author |
Maldonado, Jesús E. |
en |
dc.contributor.author |
Fleischer, Robert C. |
en |
dc.date.accessioned |
2016-12-20T23:21:38Z |
|
dc.date.available |
2016-12-20T23:21:38Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
Campana, Michael G., Parker, Lillian D., Hawkins, Melissa T. R., Young, Hillary S., Helgen, Kristofer M., Szykman Gunther, Micaela, Woodroffe, Rosie, Maldonado, Jesús E., and Fleischer, Robert C. 2016. "<a href="https%3A%2F%2Frepository.si.edu%2Fhandle%2F10088%2F30346">Genome sequence, population history, and pelage genetics of the endangered African wild dog (Lycaon pictus)</a>." <em>BMC Genomics</em>. 17 (1):1013. <a href="https://doi.org/10.1186/s12864-016-3368-9">https://doi.org/10.1186/s12864-016-3368-9</a> |
en |
dc.identifier.issn |
1471-2164 |
|
dc.identifier.uri |
https://hdl.handle.net/10088/30346 |
|
dc.description.abstract |
BACKGROUND: The African wild dog (Lycaon pictus) is an endangered African canid threatened by severe habitat fragmentation, human-wildlife conflict, and infectious disease. A highly specialized carnivore, it is distinguished by its social structure, dental morphology, absence of dewclaws, and colorful pelage. RESULTS: We sequenced the genomes of two individuals from populations representing two distinct ecological histories (Laikipia County, Kenya and KwaZulu-Natal Province, South Africa). We reconstructed population demographic histories for the two individuals and scanned the genomes for evidence of selection. CONCLUSIONS: We show that the African wild dog has undergone at least two effective population size reductions in the last 1,000,000 years. We found evidence of Lycaon individual-specific regions of low diversity, suggestive of inbreeding or population-specific selection. Further research is needed to clarify whether these population reductions and low diversity regions are characteristic of the species as a whole. We documented positive selection on the Lycaon mitochondrial genome. Finally, we identified several candidate genes (ASIP, MITF, MLPH, PMEL) that may play a role in the characteristic Lycaon pelage. |
en |
dc.relation.ispartof |
BMC Genomics |
en |
dc.title |
Genome sequence, population history, and pelage genetics of the endangered African wild dog (<I>Lycaon pictus</I>) |
en |
dc.type |
Journal Article |
en |
dc.identifier.srbnumber |
141288 |
|
dc.identifier.doi |
10.1186/s12864-016-3368-9 |
|
rft.jtitle |
BMC Genomics |
|
rft.volume |
17 |
|
rft.issue |
1 |
|
rft.spage |
1013 |
|
dc.description.SIUnit |
NH-Vertebrate Zoology |
en |
dc.description.SIUnit |
NMNH |
en |
dc.description.SIUnit |
NZP |
en |
dc.description.SIUnit |
Peer-reviewed |
en |
dc.citation.spage |
1013 |
|