dc.contributor.author |
Sholts, Sabrina B. |
en |
dc.contributor.author |
Esteban, Javier |
en |
dc.contributor.author |
Herlin, Maria |
en |
dc.contributor.author |
Viluksela, Matti |
en |
dc.contributor.author |
Håkansson, Helen |
en |
dc.date.accessioned |
2015-04-20T15:15:50Z |
|
dc.date.available |
2015-04-20T15:15:50Z |
|
dc.date.issued |
2015 |
|
dc.identifier.citation |
Sholts, Sabrina B., Esteban, Javier, Herlin, Maria, Viluksela, Matti, and Håkansson, Helen. 2015. "Craniofacial form is altered by chronic adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Han/Wistar and Long-Evans rats with different aryl hydrocarbon receptor (AhR) structures." <em>Toxicology Reports</em>. 2:472–481. <a href="https://doi.org/10.1016/j.toxrep.2014.12.007">https://doi.org/10.1016/j.toxrep.2014.12.007</a> |
en |
dc.identifier.issn |
2214-7500 |
|
dc.identifier.uri |
http://hdl.handle.net/10088/25576 |
|
dc.description.abstract |
Mammalian bone has shown a variety of responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in experimental and wildlife studies. Although many responses have been well-characterized in the postcranial skeleton, dioxin-induced effects on the cranium are largely unknown. In this study, we investigated the effects of chronic adult exposure to TCDD on cranial size and shape in dioxin-resistant Han/Wistar (H/W) and dioxin-sensitive Long-Evans (L-E) rat strains. Three-dimensional landmark configurations for the face, vault, and base of the cranium were recorded and analyzed using geometric morphometrics (GM) and dose-response modeling. The strongest effects were shown by L-E and H/W rats with daily exposures of 100 and 1000 ng TCDD/kg bw/day, respectively, resulting in significant reductions of centroid size (CS) in all three cranial modules for both strains except for the vault in H/W rats. Consistent with previous evidence of intraspecific variation in TCDD resistance, the benchmark doses (CEDs) for cranial size reduction in L-E rats were roughly 10-fold lower than those for H/W rats. For both strains, the face showed the greatest size reduction from the highest doses of TCDD (i.e., 3.6% and 6.3% decreases in H/W and L-E rats, respectively), most likely related to dose-dependent reductions in limb bone size and body weight gain. However, intrinsic morphological differences between strains were also observed: although the control groups of H/W and L-E rats had vaults and bases of comparable size, the face was 6.4% larger in L-E rats. Thus, although H/W rats possess an altered aryl hydrocarbon receptor (AhR) that appears to mediate and provides some resistance to TCDD exposure, their smaller reductions in facial size may also relate to strain-specific patterns of cranial development and growth. Future research will be aimed at understanding how ontogenetic factors may modulate toxic effects of prenatal and lactational exposure on the mammalian skeleton. |
en |
dc.relation.ispartof |
Toxicology Reports |
en |
dc.title |
Craniofacial form is altered by chronic adult exposure to 2,3,7,8-tetrachlorodibenzo-<I>p</I>-dioxin (TCDD) in Han/Wistar and Long-Evans rats with different aryl hydrocarbon receptor (AhR) structures |
en |
dc.type |
Journal Article |
en |
dc.identifier.srbnumber |
133319 |
|
dc.identifier.doi |
10.1016/j.toxrep.2014.12.007 |
|
rft.jtitle |
Toxicology Reports |
|
rft.volume |
2 |
|
rft.spage |
472 |
|
rft.epage |
481 |
|
dc.description.SIUnit |
NH-Anthropology |
en |
dc.description.SIUnit |
NMNH |
en |
dc.description.SIUnit |
Peer-reviewed |
en |
dc.citation.spage |
472 |
|
dc.citation.epage |
481 |
|