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Evolution of Linear Mitochondrial Genomes in Medusozoan Cnidarians

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dc.contributor.author Kayal, Ehsan en
dc.contributor.author Bentlage, Bastian en
dc.contributor.author Collins, Allen Gilbert en
dc.contributor.author Kayal, Mohsen en
dc.contributor.author Pirro, Stacy en
dc.contributor.author Lavrov, Dennis V. en
dc.date.accessioned 2013-09-27T12:27:30Z
dc.date.available 2013-09-27T12:27:30Z
dc.date.issued 2012
dc.identifier.citation Kayal, Ehsan, Bentlage, Bastian, Collins, Allen Gilbert, Kayal, Mohsen, Pirro, Stacy, and Lavrov, Dennis V. 2012. "<a href="https%3A%2F%2Frepository.si.edu%2Fhandle%2F10088%2F21457">Evolution of Linear Mitochondrial Genomes in Medusozoan Cnidarians</a>." <em>Genome Biology and Evolution</em>. 4 (1):1&ndash;12. <a href="https://doi.org/10.1093/gbe/evr123">https://doi.org/10.1093/gbe/evr123</a> en
dc.identifier.issn 1759-6653
dc.identifier.uri http://hdl.handle.net/10088/21457
dc.description.abstract In nearly all animals, mitochondrial DNA (mtDNA) consists of a single circular molecule that encodes several subunits of the protein complexes involved in oxidative phosphorylation as well as part of the machinery for their expression. By contrast, mtDNA in species belonging to Medusozoa (one of the two major lineages in the phylum Cnidaria) comprises one to several linear molecules. Many questions remain on the ubiquity of linear mtDNA in medusozoans and the mechanisms responsible for its evolution, replication, and transcription. To address some of these questions, we determined the sequences of nearly complete linear mtDNA from 24 species representing all four medusozoan classes: Cubozoa, Hydrozoa, Scyphozoa, and Staurozoa. All newly determined medusozoan mitochondrial genomes harbor the 17 genes typical for cnidarians and map as linear molecules with a high degree of gene order conservation relative to the anthozoans. In addition, two open reading frames (ORFs), polB and ORF314, are identified in cubozoan, schyphozoan, staurozoan, and trachyline hydrozoan mtDNA. polB belongs to the B-type DNA polymerase gene family, while the product of ORF314 may act as a terminal protein that binds telomeres. We posit that these two ORFs are remnants of a linear plasmid that invaded the mitochondrial genomes of the last common ancestor of Medusozoa and are responsible for its linearity. Hydroidolinan hydrozoans have lost the two ORFs and instead have duplicated cox1 at each end of their mitochondrial chromosome(s). Fragmentation of mtDNA occurred independently in Cubozoa and Hydridae (Hydrozoa, Hydroidolina). Our broad sampling allows us to reconstruct the evolutionary history of linear mtDNA in medusozoans. en
dc.relation.ispartof Genome Biology and Evolution en
dc.title Evolution of Linear Mitochondrial Genomes in Medusozoan Cnidarians en
dc.type Journal Article en
dc.identifier.srbnumber 109863
dc.identifier.doi 10.1093/gbe/evr123
rft.jtitle Genome Biology and Evolution
rft.volume 4
rft.issue 1
rft.spage 1
rft.epage 12
dc.description.SIUnit NH-Invertebrate Zoology en
dc.description.SIUnit NMNH en
dc.description.SIUnit Peer-reviewed en
dc.citation.spage 1
dc.citation.epage 12


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