dc.contributor.author |
Jimenez-Romero, Carlos E. |
en |
dc.contributor.author |
Torres Mendoza, Daniel |
en |
dc.contributor.author |
Ortega-Barría, Eduardo |
en |
dc.contributor.author |
McPhail, Kerry L. |
en |
dc.contributor.author |
Cubilla-Rios, Luis |
en |
dc.date.accessioned |
2012-04-12T18:51:54Z |
|
dc.date.available |
2012-04-12T18:51:54Z |
|
dc.date.issued |
2007 |
|
dc.identifier.citation |
Jimenez-Romero, Carlos E., Torres Mendoza, Daniel, Ortega-Barría, Eduardo, McPhail, Kerry L., and Cubilla-Rios, Luis. 2007. "<a href="https%3A%2F%2Frepository.si.edu%2Fhandle%2F10088%2F18304">Hydroxyalkenylresorcinols from Stylogyne turbacensis</a>." <em>Journal of Natural Products</em>. 70 (8):1249–1252. <a href="https://doi.org/10.1021/np070081d">https://doi.org/10.1021/np070081d</a> |
en |
dc.identifier.issn |
0163-3864 |
|
dc.identifier.uri |
http://hdl.handle.net/10088/18304 |
|
dc.description.abstract |
Two new compounds, 5-(11'(S)-hydroxy-8'-heptadecenyl)resorcinol (3) and 5-(12'(S)-hydroxy-8',14'-heptadecadienyl)resorcinol (4), were isolated from the leaves of Stylogyne turbacensis together with the known analogue metabolites 1 and 2. Compounds 3 and 4 showed the strongest activity in the leishmania assay, 7 and 3 M, respectively, while compounds 1, 2, and 4 showed moderate activity against a drug-resistant strain of Trypanosoma cruzi with IC50 values of 30, 25, and 22 M, respectively. Additional testing in MCF-7 and NCI-H460 was performed for compounds 3 and 4. The structures of compounds 1-4 were elucidated using NMR, MS, and other spectroscopic data. The absolute stereochemistry of compounds 3 and 4 was also investigated using the Mosher ester approach. Peracetylated derivatives of these four metabolites were produced and their activities determined in the Trypanosoma cruzi assay. |
en |
dc.relation.ispartof |
Journal of Natural Products |
en |
dc.title |
Hydroxyalkenylresorcinols from Stylogyne turbacensis |
en |
dc.type |
Journal Article |
en |
dc.identifier.srbnumber |
55521 |
|
dc.identifier.doi |
10.1021/np070081d |
|
rft.jtitle |
Journal of Natural Products |
|
rft.volume |
70 |
|
rft.issue |
8 |
|
rft.spage |
1249 |
|
rft.epage |
1252 |
|
dc.description.SIUnit |
International Collaborative Biodiversity Groups |
en |
dc.description.SIUnit |
Encyclopedia of Life |
en |
dc.description.SIUnit |
Forces of Change |
en |
dc.description.SIUnit |
STRI |
en |
dc.description.SIUnit |
filename_problems |
en |
dc.citation.spage |
1249 |
|
dc.citation.epage |
1252 |
|