dc.contributor.author |
Jimenez-Romero, Carlos E. |
en |
dc.contributor.author |
Ortega-Barría, Eduardo |
en |
dc.contributor.author |
Arnold, Anne Elizabeth |
en |
dc.contributor.author |
Cubilla-Rios, Luis |
en |
dc.date.accessioned |
2011-02-09T20:04:07Z |
|
dc.date.available |
2011-02-09T20:04:07Z |
|
dc.date.issued |
2008 |
|
dc.identifier.citation |
Jimenez-Romero, Carlos E., Ortega-Barría, Eduardo, Arnold, Anne Elizabeth, and Cubilla-Rios, Luis. 2008. "<a href="https%3A%2F%2Frepository.si.edu%2Fhandle%2F10088%2F11957">Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp</a>." <em>Pharmaceutical Biology</em>. 46 (10-11):700–703. |
en |
dc.identifier.uri |
http://hdl.handle.net/10088/11957 |
|
dc.description.abstract |
Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 µg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4Hpyran- 2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1 3 against a chloroquine-resistant Plasmodium falciparum strain. |
en |
dc.relation.ispartof |
Pharmaceutical Biology |
en |
dc.title |
Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp |
en |
dc.type |
Journal Article |
en |
dc.identifier.srbnumber |
76951 |
|
rft.jtitle |
Pharmaceutical Biology |
|
rft.volume |
46 |
|
rft.issue |
10-11 |
|
rft.spage |
700 |
|
rft.epage |
703 |
|
dc.description.SIUnit |
STRI |
en |
dc.citation.spage |
700 |
|
dc.citation.epage |
703 |
|