dc.contributor.author |
Kwan, Jason C. |
en |
dc.contributor.author |
Teplitski, Max |
en |
dc.contributor.author |
Gunasekera, Sarath |
en |
dc.contributor.author |
Paul, Valerie J. |
en |
dc.contributor.author |
Luesch, Hendrik |
en |
dc.date.accessioned |
2010-11-18T19:12:33Z |
|
dc.date.available |
2010-11-18T19:12:33Z |
|
dc.date.issued |
2010 |
|
dc.identifier.citation |
Kwan, Jason C., Teplitski, Max, Gunasekera, Sarath, Paul, Valerie J., and Luesch, Hendrik. 2010. "<a href="https%3A%2F%2Frepository.si.edu%2Fhandle%2F10088%2F11207">Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula†</a>." <em>Journal of natural products</em>. 73 (3):463–466. <a href="https://doi.org/10.1021/np900614n">https://doi.org/10.1021/np900614n</a> |
en |
dc.identifier.issn |
0163-3864 |
|
dc.identifier.uri |
http://hdl.handle.net/10088/11207 |
|
dc.description.abstract |
A new stereoisomer of malyngamide C, 8-epi-malyngamide C (1), and the known compound lyngbic acid [(4E,7S)-7-methoxytetradec-4-enoic acid] were isolated from a sample of Lyngbya majuscula collected near Bush Key, Dry Tortugas, Florida. The structure of 1 was determined by NMR and MS experiments. The absolute configuration of 1 was determined by selective Mitsunobu inversion of C-8 to give malyngamide C, as determined by NMR, MS, and comparison of specific rotation. Both 1 and malyngamide C were found to be cytotoxic to HT29 colon cancer cells (IC50 15.4 and 5.2 µM, respectively) and to inhibit bacterial quorum sensing in a reporter gene assay. |
en |
dc.relation.ispartof |
Journal of natural products |
en |
dc.title |
Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula |
en |
dc.type |
Journal Article |
en |
dc.identifier.srbnumber |
82019 |
|
dc.identifier.doi |
10.1021/np900614n |
|
rft.jtitle |
Journal of natural products |
|
rft.volume |
73 |
|
rft.issue |
3 |
|
rft.spage |
463 |
|
rft.epage |
466 |
|
dc.description.SIUnit |
NH-SMS |
en |
dc.description.SIUnit |
NMNH |
en |
dc.citation.spage |
463 |
|
dc.citation.epage |
466 |
|