DSpace Repository

Cefovecin pharmacokinetics after single-dose intramuscular administration in cheetahs (Acinonyx jubatus)

Show simple item record

dc.contributor.author Yu, Jennifer H. en
dc.contributor.author Papich, Mark G. en
dc.contributor.author Torres, Rodrigo Garces en
dc.contributor.author Emerson, Jessica en
dc.contributor.author Kinney, Matthew E. en
dc.contributor.author Helmick, Kelly en
dc.contributor.author Crosier, Adrienne en
dc.contributor.author Sanchez, Carlos R. en
dc.contributor.author Murray, Suzan en
dc.date.accessioned 2021-04-23T02:03:30Z
dc.date.available 2021-04-23T02:03:30Z
dc.date.issued 2021
dc.identifier.citation Yu, Jennifer H., Papich, Mark G., Torres, Rodrigo Garces, Emerson, Jessica, Kinney, Matthew E., Helmick, Kelly, Crosier, Adrienne, Sanchez, Carlos R., and Murray, Suzan. 2021. "Cefovecin pharmacokinetics after single-dose intramuscular administration in cheetahs (Acinonyx jubatus)." <em>Journal of veterinary pharmacology and therapeutics</em>. <a href="https://doi.org/10.1111/jvp.12969">https://doi.org/10.1111/jvp.12969</a> en
dc.identifier.issn 0140-7783
dc.identifier.uri https://hdl.handle.net/10088/110033
dc.description.abstract Cefovecin is a third-generation cephalosporin with potential value for use in exotic felids due to its long duration of action. A sparse sampling protocol was implemented with 18 zoo-housed cheetahs (Acinonyx jubatus) to evaluate the pharmacokinetics of cefovecin (Convenia(R)) after a single 8 mg/kg intramuscular injection. Blood was collected serially for 15 days following administration, and plasma cefovecin concentrations were determined using high-pressure liquid chromatography with ultraviolet detection. Pharmacokinetic parameters were estimated using population pharmacokinetic methods and non-linear mixed effects modeling (NLME). Cefovecin was well tolerated by all cats, with no adverse effects observed. Peak plasma cefovecin concentration was 84.75 mu g/ml, with a mean residence time of 207.9 h and an elimination half-life of 144.1 h (6.00 days). Plasma concentrations of cefovecin were maintained &gt;7 mu g/ml in all individuals for the entire study duration (15 days). These concentrations are lower, and the half-life slightly shorter, than the values reported for domestic cats. Cefovecin was highly protein-bound (approximately 99.9%) in cheetah plasma, which is nearly identical to domestic cats. These results indicate that cefovecin is potentially useful as a long-acting antibiotic in cheetahs. en
dc.relation.ispartof Journal of veterinary pharmacology and therapeutics en
dc.title Cefovecin pharmacokinetics after single-dose intramuscular administration in cheetahs (Acinonyx jubatus) en
dc.type Journal Article en
dc.identifier.srbnumber 159127
dc.identifier.doi 10.1111/jvp.12969
rft.jtitle Journal of veterinary pharmacology and therapeutics
dc.description.SIUnit NZP en

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account