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Glomerular filtration rate determined by measuring serum clearance of a single dose of inulin and serum symmetric dimethylarginine concentration in clinically normal cheetahs (<I>Acinonyx jubatus</I>)

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dc.contributor.author Sanchez, Carlos R. en
dc.contributor.author Hayek, Lee-Ann C. en
dc.contributor.author Carlin, Ellen P. en
dc.contributor.author Brown, Scott A. en
dc.contributor.author Citino, Scott en
dc.contributor.author Marker, Laurie en
dc.contributor.author Jones, Krista L. en
dc.contributor.author Murray, Suzan en
dc.date.accessioned 2020-04-07T02:03:29Z
dc.date.available 2020-04-07T02:03:29Z
dc.date.issued 2020
dc.identifier.citation Sanchez, Carlos R., Hayek, Lee-Ann C., Carlin, Ellen P., Brown, Scott A., Citino, Scott, Marker, Laurie, Jones, Krista L., and Murray, Suzan. 2020. "<a href="https://avmajournals.avma.org/doi/full/10.2460/ajvr.81.4.375">Glomerular filtration rate determined by measuring serum clearance of a single dose of inulin and serum symmetric dimethylarginine concentration in clinically normal cheetahs (Acinonyx jubatus)</a>." <em>American Journal of Veterinary Research</em>. 81 (4):375&ndash;380. <a href="https://doi.org/10.2460/ajvr.81.4.375">https://doi.org/10.2460/ajvr.81.4.375</a> en
dc.identifier.issn 0002-9645
dc.identifier.uri https://hdl.handle.net/10088/105143
dc.description.abstract OBJECTIVE To establish a reference interval for glomerular filtration rate (GFR) determined by measuring serum clearance of a single IV dose of inulin in clinically normal cheetahs (Acinonyx jubatus) and compare serum symmetric dimethylarginine (SDMA) concentration in cheetahs with GFR. ANIMALS 33 cheetahs housed at 3 institutions. PROCEDURES A single bolus of inulin (3,000 mg/m2) was administered IV, and 5 serial blood samples were collected and analyzed for serum inulin concentration with the anthrone technique. The GFR was estimated with a modified slope-intercept method for the slow component of the serum concentration-versus-time curve. Blood urea nitrogen and serum creatinine concentrations were measured in samples obtained immediately prior to inulin administration, and serum SDMA concentration was measured in stored samples. RESULTS Mean ± SD measured GFR was 1.58 ± 0.39 mL/min/kg, and the calculated reference interval was 0.84 to 2.37 mL/min/kg. There were significant negative correlations between GFR and serum creatinine concentration (r = -0.499), BUN concentration (r = -0.592), and age (r = -0.463). Serum SDMA concentration was not significantly correlated with GFR (r = 0.385), BUN concentration (r = -0.281), or serum creatinine concentration (r = 0.165). CONCLUSIONS AND CLINICAL RELEVANCE A reference interval for GFR in clinically normal cheetahs was obtained. Further evaluation of animals with renal disease is needed to determine whether measuring serum clearance of a single IV dose of inulin is a reliable diagnostic test for early detection of renal disease in cheetahs. en
dc.relation.ispartof American Journal of Veterinary Research en
dc.title Glomerular filtration rate determined by measuring serum clearance of a single dose of inulin and serum symmetric dimethylarginine concentration in clinically normal cheetahs (<I>Acinonyx jubatus</I>) en
dc.type Journal Article en
dc.identifier.srbnumber 154880
dc.identifier.doi 10.2460/ajvr.81.4.375
rft.jtitle American Journal of Veterinary Research
rft.volume 81
rft.issue 4
rft.spage 375
rft.epage 380
dc.description.SIUnit NZP en
dc.citation.spage 375
dc.citation.epage 380
dc.relation.url https://avmajournals.avma.org/doi/full/10.2460/ajvr.81.4.375


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