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Browsing by Author "Gunasekera, Sarath P."

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Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium Caldora sp. Collected from the Reefs of Fort Lauderdale, Florida

Gunasekera, Sarath P.; Kokkaliari, Sofia; Ratnayake, Ranjala; Sauvage, Thomas; dos Santos, Larissa A. H.; Luesch, Hendrik; Paul, Valerie J. (2022)

Dysidazirine carboxylic acid (1) was isolated from the lipophilic extract of a collection of the benthic marine cyanobacterium Caldora sp. from reefs near Fort Lauderdale, Florida. The planar structure of this new compound ...
Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata

Gunasekera, Sarath P.; Imperial, Lorelie; Garst, Christiana; Ratnayake, Ranjala; Dang, Long H.; Paul, Valerie J.; Luesch, Hendrik (2016)

The isolation, structure determination, and biological activities of a new linear pentapeptide, caldoramide (5), from the marine cyanobacterium Caldora penicillata from Florida are described. Caldoramide (5) has structural ...
Carriebowlinol, an Antimicrobial Tetrahydroquinolinol from an Assemblage of Marine Cyanobacteria Containing a Novel Taxon

Soares, Angélica R.; Engene, Niclas; Gunasekera, Sarath P.; Sneed, Jennifer M.; Paul, Valerie J. (2015)

A combined biodiversity- and bioassay-guided natural products discovery approach was used to explore new groups of marine cyanobacteria for novel secondary metabolites with ecologically relevant bioactivities. Phylogenetic ...
Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease

Ushijima, Blake; Gunasekera, Sarath P.; Meyer, Julie L.; Tittl, Jessica; Pitts, Kelly A.; Thompson, Sharon; Sneed, Jennifer M.; Ding, Yousong; Chen, Manyun; Jay Houk, L.; Aeby, Greta S.; Häse, Claudia C.; Paul, Valerie J. (2023)

Abstract Considered one of the most devastating coral disease outbreaks in history, stony coral tissue loss disease (SCTLD) is currently spreading throughout Florida’s coral reefs and the greater Caribbean. SCTLD affects ...
Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles

Gunasekera, Sarath P.; Meyer, Julie L.; Ding, Yousong; Abboud, Khalil A.; Luo, Danmeng; Campbell, Justin E.; Angerhofer, Alexander; Goodsell, Justin L.; Raymundo, Laurie J.; Liu, Junyang; Ye, Tao; Luesch, Hendrik; Teplitski, Max; Paul, Valerie J. (2019)
Cryptic Diversity of Black Band Disease Cyanobacteria in Siderastrea siderea Corals Revealed by Chemical Ecology and Comparative Genome-Resolved Metagenomics

Meyer, Julie L.; Gunasekera, Sarath P.; Brown, Anya L.; Ding, Yousong; Miller, Stephanie; Teplitski, Max; Paul, Valerie J. (2023)

Black band disease is a globally distributed and easily recognizable coral disease. Despite years of study, the etiology of this coral disease, which impacts dozens of stony coral species, is not completely understood. ...
Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria

Liang, Xiao; Luo, Danmeng; Yan, Jia-Lei; Rezaei, Mohammad A.; Salvador-Reyes, Lilibeth; Gunasekera, Sarath P.; Li, Chenglong; Ye, Tao; Paul, Valerie J.; Luesch, Hendrik (2019)
Discovery, Synthesis, and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium, Hormoscilla sp br

Brumley, David A.; Gunasekera, Sarath P.; Sauvage, Thomas; dos Santos, Larissa A. H.; Chen, Qi-Yin; Paul, Valerie J.; Luesch, Hendrik (2022)

Our ongoing efforts to explore the chemical space associated with marine cyanobacteria from coral reefs of Guamhave yielded two new members of the anaenamide family ofnatural products, anaenamides C (3)and D (4). Thesecompounds ...
Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria

Gunasekera, Sarath P.; Li, Yang; Ratnayake, Ranjala; Luo, Danmeng; Lo, Jeannette; Reibenspies, Joseph H.; Xu, Zhengshuang; Clare-Salzler, Michael; Ye, Tao; Paul, Valerie J.; Luesch, Hendrik (2016)

A new dimeric macrolide xylopyranoside, cocosolide (1), was isolated from the marine cyanobacterium preliminarily identified as Symploca sp. from Guam. The structure was determined by a combination of NMR spectroscopy, ...
Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore

Brumley, David A.; Gunasekera, Sarath P.; Chen, Qi-Yin; Paul, Valerie J.; Luesch, Hendrik (2020)
Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1a Mediated Cancer Cell Viability and Vascularization

Ratnayake, Ranjala; Gunasekera, Sarath P.; Ma, Jia Jia; Dang, Long H.; Carney, Thomas; Paul, Valerie J.; Luesch, Hendrik (2020)

Chemical investigation of a benthic marine cyanobacterium yielded the anticancer agent dolastatin 15, originally isolated from a mollusk. Dolastatin 15 is a microtubule destabilizing agent with analogues undergoing clinical ...
Eudesmacarbonate, a Eudesmane-Type Sesquiterpene from a Marine Filamentous Cyanobacterial Mat (Oscillatoriales) in the Florida Keys

Lydon, Christina A.; Mathivathanan, Logesh; Sanchez, Juanita; Dos Santos, Larissa A. H.; Sauvage, Thomas; Gunasekera, Sarath P.; Paul, Valerie J.; Berry, John P. (2020)

A new, cyclic carbonate eudesmane-type sesquiterpene, eudesmacarbonate (1), was isolated from marine filamentous cyanobacterial mats associated with apparent ingestion-related intoxications of captive bottlenose dolphins ...
Isolation and Characterization of Anaephenes A–C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales)

Brumley, David; Spencer, Kara A.; Gunasekera, Sarath P.; Sauvage, Thomas; Biggs, Jason; Paul, Valerie J.; Luesch, Hendrik (2018)
Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam

Gunasekera, Sarath P.; Owle, Chivas S.; Montaser, Rana; Luesch, Hendrik; Paul, Valerie J. (2011)
Microbiome shifts and the inhibition of quorum sensing by Black Band Disease cyanobacteria

Meyer, Julie L.; Gunasekera, Sarath P.; Scott, Raymond M.; Paul, Valerie J.; Teplitski, Max (2016)

Disruption of the microbiome often correlates with the appearance of disease symptoms in metaorganisms such as corals. In Black Band Disease (BBD), a polymicrobial disease consortium dominated by the filamentous cyanobacterium ...
Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp

Meickle, Theresa; Gunasekera, Sarath P.; Liu, Yanxia; Luesch, Hendrik; Paul, Valerie J. (2011)
Quorum-sensing inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat

Abed, Raeid M. M.; Dobretsov, Sergey; Al-Fori, Marwan; Gunasekera, Sarath P.; Sudesh, Kumar; Paul, Valerie J. (2013)

In this study, extremely halophilic and moderately thermophilic microorganisms from a hypersaline microbial mat were screened for their ability to produce antibacterial, antidiatom, antialgal, and quorum-sensing (QS) ...

Browsing by Author "Gunasekera, Sarath P."

Browsing by Author "Gunasekera, Sarath P."

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